I'm not going to come here and act as if you should always leave every secure thing you have behind and chase every random dream. Sometimes that's simply not the best road to take, and you should, for example, save a little money first, or wait it out, land a remote job and travel with a stable income; I mean, there are countless safer options than leaving everything behind with no backup.
When we have these big desires, such as travelling the world, we seldom think that there is limited time to make them come true. Of course, technically there isn't; you could potentially travel the world at 60, but how can we be sure what our situation will be like at that age?
Settling isn't the end of the world; you can travel if you have a partner and a family, but it's true that it makes matters more complicated. To me, the central things are desire and how burnt out you are from your current job.
This employee says he has already paid his student loan and has savings; the only thing holding him back would be guilt, but are we willing to sacrifice our whole lives to guilt? What would we get in exchange? More stress and a day-to-day life that feels pointless?
The decision doesn't have to be that drastic, really. You can take only a year off and come back. If you already started your career and have some experience, the year-long gap won't look as bad on your resume if you can justify it with a random 'experience-building' paragraph.
What would you do? Wait it out till the next holiday and keep your steady job? Or go on the adventure, relax, and rethink your life?