Duke closes its non-conference schedule on Saturday with a matchup against FCS member William & Mary. The Blue Devils enter the game 3-0 after wins against Tulane, Illinois and Stanford, while the Tribe are 2-2 after losing their last two games.

Nate Sheppard continues to lead Duke’s offense on the ground, leading the nation in all-purpose and rushing yards through three weeks, while quarterback Walker Eget looks to click even more in the passing offense. Duke’s defense has been a stalwart since the second half of the Illinois game, allowing just 10 points in the last 90 minutes.

Duke and William & Mary kick off at 3:30 p.m. ET at Wallace Wade Stadium.

Get real-time updates, scoring plays, turning points, and expert analysis throughout Duke’s game against William & Mary. Follow along for highlights, injury news, key plays, and instant breakdown.

Duke vs. William & Mary scoreQuarterQ1Q2Q3Q4—ScoreDuke––––—xxWilliam & Mary––––—Xx02:30 PM ET, September 25 2026, Brian StultzHow to watch Duke vs. William & Mary: TV channel, streaming info
  • TV Channel: ACC Network Extra
  • Livestream: Fubo (free trial)
  • Duke vs. William & Mary will air on ACC Network Extra in Week 4 of the 2026 college football season. Kevin Fitzgerald (play-by-play) and Jeff Woody (analyst) will call the game from the booth at Wallace Wade Stadium. You can stream the game on FUBO, which offers a free trial to new subscribers.
Duke vs. William & Mary weather forecast
  • Forecasts for Saturday afternoon in Durham call for sunny skies with a high of 78 and zero percent chance of rain.
Duke vs. William & Mary predictions, betting odds

Odds via BetMGM.

  • Duke 45, William & Mary 6. If I were playing this game on PlayStation, I would run Nate Sheppard over and over again until he puts up massive numbers that can’t be ignored by the national media. Yet this game is played in reality, and therefore overworking the stud running back would be coaching malpractice. Still, Sheppard will go for 150-plus yards and a couple of touchdowns, while Walker Eget and the passing game look to get into even more rhythm as Duke wins big. - Brian Stultz
  • Spread: Duke (-43.5)
  • Total O/U: 62.5
  • Moneyline: Unlisted (heavy favorite)
Duke vs. William & Mary injury updates, inactives
  • Duke - OUT: WR Qeanu Johnson, QB Lawrence Gardner, OL Roman Fina, OL Reagan McCranie, OL Kai Jacobwitz; QUESTIONABLE: CB DaShawn Stone, S Brady Winter, OL Micah Sahakian, CB Kimari Robinson
  • William & Mary: N/A

This article originally appeared on Duke Wire: Duke vs. William & Mary live updates: Score, highlights, predictions, analysis